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The endothelial-enriched lncRNA LINC00607 mediates angiogenic function |
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Poison cassette exon splicing of SRSF6 regulates nuclear speckle dispersal and the response to hypoxia |
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Computational Methods to Study DNA:DNA:RNA Triplex Formation by lncRNAs |
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A Tedious Journey: Cardiomyocyte Proliferation Requires More Than S-Phase Entry and Loss of Polyploidization | | Ding D, Braun T | Circulation | 2023 | | |
The emerging landscape of non-conventional RNA functions in atherosclerosis |
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A universal model of RNA.DNA:DNA triplex formation accurately predicts genome-wide RNA–DNA interactions |
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High-throughput optical action potential recordings in hiPSC-derived cardiomyocytes with a genetically encoded voltage indicator in the AAVS1 locus |
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Unravelling the impact of aging on the human endothelial lncRNA transcriptome |
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HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex |
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Replication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells |
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Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2 |
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Linking single nucleotide polymorphisms to signaling blueprints in abdominal aortic aneurysms |
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Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants |
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Quo Vadis? Immunodynamics of Myeloid Cells after Myocardial Infarction |
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Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine |
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ADAR1 Prevents Autoinflammatory Processes in the Heart Mediated by IRF7 |
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Aging-regulated TUG1 is dispensable for endothelial cell function |
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Genetic and modifiable risk factors combine multiplicatively in common disease |
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Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1 |
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Calcium-Controlled Reactive Oxygen Species Afterburner Perpetuates Endothelial Damage After Radiation Therapy |
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Accelerating cardiovascular research: recent advances in translational 2D and 3D heart models |
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Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression |
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Orphan GPR26 Counteracts Early Phases of Hyperglycemia-Mediated Monocyte Activation and Is Suppressed in Diabetic Patients |
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Colchicine Impacts Leukocyte Trafficking in Atherosclerosis and Reduces Vascular Inflammation |
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The G3BP1-UPF1-Associated Long Non-Coding RNA CALA Regulates RNA Turnover in the Cytoplasm |
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Conformational Effects of a Cancer-Linked Mutation in Pri-miR-30c RNA |
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Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs |
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MicroRNAs as therapeutic targets in cardiovascular disease |
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Mechano-signaling via Piezo1 prevents activation and p53-mediated senescence of muscle stem cells |
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Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors |
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The splicing‐regulatory lncRNA NTRAS sustains vascular integrity |
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Neonatal injury models: integral tools to decipher the molecular basis of cardiac regeneration |
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Generation of heterozygous (MRli003-A-5) and homozygous (MRli003-A-6) voltage-sensing knock-in human iPSC lines by CRISPR/Cas9 editing of the AAVS1 locus |
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MicroRNA-26b Attenuates Platelet Adhesion and Aggregation in Mice |
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Exercise-Induced Long Noncoding RNAs As New Players in Cardiac Hypertrophy |
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miR-486 attenuates cardiac ischemia/reperfusion injury and mediates the beneficial effect of exercise for myocardial protection | | Bei Y, Lu D, (...), Xiao J | Molecular Therapy | 2022 | | |
Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes |
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Generation of heterozygous (MRli003-A-3) and homozygous (MRli003-A-4) TRPM4 knockout human iPSC lines |
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Interdependence of Angiogenesis and Arteriogenesis in Development and Disease |
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Cardiac remodelling – Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology | | González A, Richards AM, (...), Bayés‐Genís A | European Journal of Heart Failure | 2022 | | |
Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease | | Santovito D, Weber C | Nature Reviews Cardiology | 2022 | | |
Nicht kodierende Ribonukleinsäure im kardiovaskulären System |
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Properties and fate of human mesenchymal stem cells upon miRNA let-7f-promoted recruitment to atherosclerotic plaques |
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Development and characterization of anti-fibrotic natural compound similars with improved effectivity |
| Kreutzer FP, Meinecke A, (...), Thum T | Basic Research in Cardiology | 2022 | | |
A Non-Canonical Link between Non-Coding RNAs and Cardiovascular Diseases |
| Natarelli L, Weber C | Biomedicines | 2022 | | |
Use of hiPSC-Derived Cardiomyocytes to Rule Out Proarrhythmic Effects of Drugs: The Case of Hydroxychloroquine in COVID-19 |
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Cell cycle defects underlie childhood-onset cardiomyopathy associated with Noonan syndrome |
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Endothelial Retargeting of AAV9 In Vivo |
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MicroRNA-365 regulates human cardiac action potential duration |
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Human Macrophage Long Intergenic Noncoding RNA, SIMALR, Suppresses Inflammatory Macrophage Apoptosis via NTN1 (Netrin-1) | | Cynn E, Li DY, (...), Reilly MP | Arterioscler Thromb Vasc Biol | 2022 | | |
Emerging epigenetic therapies of cardiac fibrosis and remodelling in heart failure: from basic mechanisms to early clinical development |
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Functional RNA Dynamics Are Progressively Governed by RNA Destabilization during the Adaptation to Chronic Hypoxia |
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A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity |
| Lu D, Chatterjee S, (...), Thum T | Eur Heart J | 2022 | | |
Control of CRK-RAC1 activity by the miR-1/206/133 miRNA family is essential for neuromuscular junction function |
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Integrative analysis of epigenetics data identifies gene-specific regulatory elements |
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Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC) |
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Concomitant Activation of OSM and LIF Receptor by a Dual-Specific hlOSM Variant Confers Cardioprotection after Myocardial Infarction in Mice |
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Ryanodine Receptors Matter for Cardiac Function in Duchenne Muscular Dystrophy |
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Polygenic risk for coronary artery disease in the Scottish and English population |
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Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load |
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Generation of heterozygous (MRli003-A-1) and homozygous (MRli003-A-2) MYH10 knockout human iPSC lines |
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The long non-coding RNA NRON promotes the development of cardiac hypertrophy in the murine heart | | Hoepfner J, Leonardy J, (...), Thum T | Molecular Therapy | 2021 | | |
Long non-coding RNAs: novel regulators of cellular physiology and function |
| Oo JA, Brandes RP, Leisegang MS | Pflügers Archiv - European Journal of Physiology | 2021 | | |
Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Responses |
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Non-coding RNAs: key regulators of reprogramming, pluripotency, and cardiac cell specification with therapeutic perspective for heart regeneration |
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Sequential Defects in Cardiac Lineage Commitment and Maturation Cause Hypoplastic Left Heart Syndrome |
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Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization |
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Repression of Osmr and Fgfr1 by miR-1/133a prevents cardiomyocyte dedifferentiation and cell cycle entry in the adult heart |
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Risk Prediction of Cardiovascular Events by Exploration of Molecular Data with Explainable Artificial Intelligence |
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1H, 13C and 15N assignment of stem-loop SL1 from the 5'-UTR of SARS-CoV-2 |
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Parallel Murine and Human Aortic Wall Genomics Reveals Metabolic Reprogramming as Key Driver of Abdominal Aortic Aneurysm Progression |
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Increased presence of nuclear DNAJA3 and upregulation of cytosolic STAT1 and of nucleic acid sensors trigger innate immunity in the ClpP-null mouse |
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Coronary Artery Disease Genetics Enlightened by Genome-Wide Association Studies |
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Understanding Arteriosclerosis 2.0: Making Sense of Genetic Variants with scATAC |
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Genetics of coronary artery disease in the post‐GWAS era |
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Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility |
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AntimiR-132 Attenuates Myocardial Hypertrophy in an Animal Model of Percutaneous Aortic Constriction | | Hinkel R, Batkai S, (...), Kupatt C | Journal of the American College of Cardiology | 2021 | | |
Not all myocardial infarctions are created equal: The potential of circulating microRNAs to discern coronary artery dissection |
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Cis-epistasis at the LPA locus and risk of cardiovascular diseases |
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Progressive stretch enhances growth and maturation of 3D stem-cell-derived myocardium |
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Non-coding RNAs in Cardiac Regeneration |
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MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease |
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MicroRNAs and Long Non-Coding RNAs as Potential Candidates to Target Specific Motifs of SARS-CoV-2 |
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Inflammation-Related Risk Loci in Genome-Wide Association Studies of Coronary Artery Disease |
| Mauersberger C, Schunkert H, Sager HB | Cells | 2021 | | |
Cas9-expressing chickens and pigs as resources for genome editing in livestock |
| Rieblinger B, Sid H, (...), Schusser B | Proceedings of the National Academy of Sciences | 2021 | | |
Plasma microRNA signature associated with retinopathy in patients with type 2 diabetes |
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Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation |
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MicroRNA-21–Dependent Macrophage-to-Fibroblast Signaling Determines the Cardiac Response to Pressure Overload |
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Genome editing for Duchenne muscular dystrophy: a glimpse of the future? |
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Impaired complex I repair causes recessive Leber’s hereditary optic neuropathy |
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Blood-based protein profiling identifies serum protein c-KIT as a novel biomarker for hypertrophic cardiomyopathy |
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Long Non-coding RNA Aerrie Controls DNA Damage Repair via YBX1 to Maintain Endothelial Cell Function |
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Noncoding RNAs in Vascular Diseases |
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Prediction of single-cell gene expression for transcription factor analysis |
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Plasma circular RNA hsa_circ_0001445 and coronary artery disease: Performance as a biomarker |
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Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy | | Moretti A, Fonteyne L, (...), Kupatt C | Nature Medicine | 2020 | | |
Functional investigation of the coronary artery disease gene SVEP1 |
| Winkler MJ, Müller P, (...), Kessler T | Basic Research in Cardiology | 2020 | | |
ZNF354C is a transcriptional repressor that inhibits endothelial angiogenic sprouting |
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Inositol‐requiring enzyme‐1 regulates phosphoinositide signaling lipids and macrophage growth |
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Beyond the RNA-dependent function of LncRNA genes |
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Autophagy unleashes noncanonical microRNA functions |
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Precise Correction of Heterozygous SHOX2 Mutations in hiPSCs Derived from Patients with Atrial Fibrillation via Genome Editing and Sib Selection |
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Linc‐MYH configures INO80 to regulate muscle stem cell numbers and skeletal muscle hypertrophy |
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Should We Use Genetic Scores in the Determination of Treatment Strategies to Control Dyslipidemias? | | Lechner K, Kessler T, Schunkert H | Current Cardiology Reports | 2020 | | |
Dynamic mRNP Remodeling in Response to Internal and External Stimuli |
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MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes |
| Lu D, Chatterjee S, (...), Thum T | Journal of Molecular and Cellular Cardiology | 2020 | | |
Agrin Promotes Coordinated Therapeutic Processes Leading to Improved Cardiac Repair in Pigs |
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Noncoding RNAs in Cardiovascular Disease: Current Knowledge, Tools and Technologies for Investigation, and Future Directions: A Scientific Statement From the American Heart Association |
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Genetically determined intelligence and coronary artery disease risk |
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Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart |
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Small Things Matter: Relevance of MicroRNAs in Cardiovascular Disease |
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Deep Characterization of Circular RNAs from Human Cardiovascular Cell Models and Cardiac Tissue |
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Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis | | Santovito D, Egea V, (...), Weber C | Science Translational Medicine | 2020 | | |
Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function |
| Stanicek L, Lozano-Vidal N, (...), Boon RA | Communications Biology | 2020 | | |
EpiRegio: analysis and retrieval of regulatory elements linked to genes |
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SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications |
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Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction |
| Trembinski DJ, Bink DI, (...), Boon RA | Nature Communications | 2020 | | |
AntimiR-21 Prevents Myocardial Dysfunction in a Pig Model of Ischemia/Reperfusion Injury |
| Hinkel R, Ramanujam D, (...), Engelhardt S | Journal of the American College of Cardiology | 2020 | | |
Thymosin beta-4x LINCs SPAAR to its non-coding function |
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Statins Make a Difference in Acute Myocardial Infarction |
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Circular RNAs: A Novel Class of Functional RNA Molecules with a Therapeutic Perspective |
| Santer L, Bär C, Thum T | Molecular Therapy | 2019 | | |
Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy |
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Long noncoding RNAs in key cellular processes involved in aortic aneurysms |
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Linking obesity with abdominal aortic aneurysm development |
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